Swezey, C. M. Introduction.--The burden of the ethical.--Faith, unbelief, and moral life.--Education for moral responsibility.--The theologian as prophet, preserver, or participant.--Moral discernment in the Christian life.--The place of Scripture in Christian ethics.--The relation of the Gospels to the moral life.--Spiritual life and moral life.--The relevance of historical understanding.--Man--in light of social science and Christian faith.--The relationship of empirical science to moral thought.--What is the normatively human?--Basic ethical issues in the biomedical fields.--Genetic engineering and the normative view of the human.--Bibliography of (...) the writings of James M. Gustafson, 1951-1973 (p. 297-305). (shrink)

In his 1994 A Sense of the Divine: The Natural Environment from a Theocentric Perspective, James M. Gustafson offered a long-awaited application of his theocentric ethics. In Intersections Gustafson continues to insist that theology and theological ethics must overlap with other, diverse fields of study -- particularly the hard sciences -- if they are to remain rich, vital, and relevant in the years ahead. With trademark clarity, he relentlessly pursues the fundamental questions of theological ethics: the nature of (...) being human, what distinguishes us from other species, how our self-interest conflicts with our sympathy and concern for others, and the role of religious faith. After contrasting two interpretations of human nature -- one from theologian Reinhold Niebuhr, the other from biologist Melvin Konner -- Gustafson suggests four modes of moral discourse about medicine, then examines styles of religious reflection in medical ethics. Briefly sharpening his focus on genetic therapy, he moves to larger questions of human viability, concluding with a stirring call to scholars, clergy, and laypersons alike to engage in these intellectual intersections -- intersections that have, above all, supreme practical importance in our daily lives. (shrink)

Determines the implications of Christian religious conviction for moral conduct through extensive philosophical inquiry into an incident involving an ethical ...

Moral evaluations of medical research and care focus on different issues, e.g., clinical choices, public policy and cultural values. Technical ethical concepts and arguments do not suffice for all issues. Analysis of the literature suggests that, in addition to ethical discourse, prophetic, narrative, and policy discourse function morally. The article characterizes each of these forms, and suggests the insufficiency of each if it is taken to be the only mode of analysis. Keywords: ethics, narrative, policy, prophecy CiteULike Connotea Del.icio.us What's (...) this? (shrink)

. . . This brilliant and tightly argued book . . . will be the most important book on moral theology to appear this year."—John Coleman, National Catholic Reporter.

This essay is an experimental project. It proposes that the theme of participation issues in an insightful, distinctive, comprehensive, and coherent interpretation of human experience. My personal history is a test case.

Ultimately for Christian ethics, a biblically informed theology provides the bases for the final test of the validity of particular judgments: For Christians these judgments ought to be consistent, consonant, and coherent with the themes that are generalized to be most pervasive or primary in the biblical witness.

"_Ethics from a Theocentric Perspective_ will surprise some, shock others, and unleash a flood of speculation about what has happened to James Gustafson. The answer quite simply is nothing has happened to Gustafson except that he has now turned his attention to developing his constructive theological position, and we should all be very glad.... In this, the first of two volumes, Gustafson displays his colors as a constructive theologian, and they are indeed brilliant and splendid.... Though (...) class='Hi'>Gustafson is a theologian who works in the Christian tradition, he reminds us that the God Christians worship is not merely the Christian God. For Gustafson the kind of God who is the object of the theologians's reflection eludes or surpasses the inevitably confessional activity of Christian theological reflection. Thus Gustafson, the constructive theologian, is also Gustafson the revisionist theologian who takes as his task nothing less than challenging the anthropocentrism that he alleges characterizes mainstream Western Christian theology."—Stanley Hauerwas, _Journal of Religion_. (shrink)

Book reviewed in this article: On Human Nature. By Edward O. Wilson.

A study in ethics: a statement of procedure and method -- Jesus Christ, the Lord who is creator and redeemer -- Jesus Christ, the sanctifier -- Jesus Christ, the justifier -- Jesus Christ, the pattern -- Jesus Christ, the teacher -- Christ and the moral life: a constructive statement.

A comparison of E.O. Wilson's On Human Nature and Abraham Heschel's Who Is Man? introduces a discussion of how descriptions and explanations of the human are related to valuations of the human. More intense comparative analysis focuses on Melvin Konner, The Tangled Wing, and Reinhold Niebuhr, The Nature and Destiny of Man, Similarities of outlook toward life in the world are noted, although the supporting information, concepts, and arguments are radically different. The article illustrates how a subject matter, here the (...) human, that is addressed by different disciplines and methods can yield fruitful interdisciplinary analysis. (shrink)

Theology and ethics intersect with sciences at different points depending upon whether the scholars involved are interested in, for example, general epistemological issues or practical moral judgments. The intersection affects theology and ethics in different ways, depending upon various commitments or resistances on the part of theologians. The author surveys his own writings to show how openness to the sciences has had an impact on various phases of his work and what issues remain somewhat unresolved.

All three articles properly locate my work as interactive between the sciences on the one hand and theology and ethics on the other. They disagree on whether tradition, science, or experience “trumps” the others when they conflict; Beckley shows the importance of tradition, which is slighted by the other two. Comments on each article indicate where further discussion is needed and where I have learned from the authors or agree with them.

Sexually reproducing metazoans establish a cell lineage during development that is ultimately dedicated to gamete production. Work in a variety of animals suggests that a group of conserved molecular determinants act in this germ line maintenance and function. The most universal of these genes are Vasa and Vasa‐like DEAD‐box RNA helicase genes. However, recent evidence indicates that Vasa genes also function in other cell types, distinct from the germ line. Here we evaluate our current understanding of Vasa function and its (...) regulation during development, addressing Vasa's emerging role in multipotent cells. We also explore the evolutionary diversification of the N‐terminal domain of this gene and how this impacts the association of Vasa with nuage‐like perinuclear structures. (shrink)

The Responsible Self was H. Richard Niebuhr's most important work in Christian ethics. In it he probes the most fundamental character of the moral life and it stands today as a landmark contribution to the field. The Library of Theological Ethics series focuses on what it means to think theologically and ethically. It presents a selection of important and otherwise unavailable texts in easily accessible form. Volumes in this series will enable sustained dialogue with predecessors though reflection on classic works (...) in the field. (shrink)

Authority in Morals: An Essay in Christian Ethics. By Gerard J. Hughes On Human Nature. By Edward O. Wilson Democracy and Ethical Life. By Claes G. Ryn The Foundations of Modern Political Thought. By Quentin Skinner. 2 vols. Phenomenology and the Social World: the Philosophy of Merleau‐Ponty and its Relation to the Social Conscience. By Laurie Spurting Philosophical Foundations of the Three Sociologies. By Ted Benton Christianity and the World Order. By Edward Norman. Oxford, Oxford University Press, 1979, £3.50. The (...) Stoics. Edited by John M. Rist Descartes. By Margaret D. Wilson Physicalism. By K.V. Wilkes Kierkegaard as Educator. By R.J. Manheimer Two Ages: The Age of Revolution and the Present Age. By Søren Kierkegaard, translated and edited by Howard and Edna Hong Parables of Kierkegaard. Edited by Thomas C. Oden Thomas Carlyle: ‘Cahinist without the Theology’. By Eloise M. Behnken The Praise of 'Sons of Bitches’. By James V. Schall The Inner Eye of Love. By William Johnston The River Within. By Christopher Bryant The Religious Imagination and the Sense of God. By John Bowker Old Testament Theology: A Fresh Approach. By Ronald E. Clements What is a Gospel? By Charles H. Talbert Urchristliche Prophetic. By Gerhard Dautzenberg Amphttochii Icontensis Opera. Edited by Cornells Datema Man and Nature in the Renaissance. By Allen G. Debus The Church in Late Victorian Scotland 1874–1900. By Andrew L. Drummond and James Bullock. Ppix, 342, Edinburgh, The St Andrew Press, 1978, £10.50. From Office to Profession: The New England Ministry 1750–1860. By Donald M. Scott Bemard‐Lazare: Anti‐Semitism and the Problem of Jewish Identity in Late Nineteenth Century France. By Nelly Wilson. (shrink)

Book reviewed in this article: Jewish Bioethics. Edited by Fred Rosner and J. David Bleich.

To localize wheat ESTs on chromosomes, 882 homoeologous group 6-specific ESTs were identified by physically mapping 7965 singletons from 37 cDNA libraries on 146 chromosome, arm, and sub-arm aneuploid and deletion stocks. The 882 ESTs were physically mapped to 25 regions flanked by 23 deletion breakpoints. Of the 5154 restriction fragments detected by 882 ESTs, 2043 were localized to group 6 chromosomes and 806 were mapped on other chromosome groups. The number of loci mapped was greatest on chromosome 6B and (...) least on 6D. The 264 ESTs that detected orthologous loci on all three homoeologs using one restriction enzyme were used to construct a consensus physical map. The physical distribution of ESTs was uneven on chromosomes with a tendency toward higher densities in the distal halves of chromosome arms. About 43% of the wheat group 6 ESTs identified rice homologs upon comparisons of genome sequences. Fifty-eight percent of these ESTs were present on rice chromosome 2 and the remaining were on other rice chromosomes. Even within the group 6 bins, rice chromosomal blocks identified by 1-6 wheat ESTs were homologous to up to 11 rice chromosomes. These rice-block contigs were used to resolve the order of wheat ESTs within each bin. (shrink)

A critical review essay of The Child's Theory of Mind, Henry M. Wellman, 1992, Cambridge, MA, MIT Press, xiii + 358 pp, $16.95; and Young Children's Understanding of Pretense, Paul L. Harris, Robert D. Kavanaugh, 1993, with Commentary by Henry M. Wellman, Anne K. Hickling and a Reply by the authors. Monographs of the Society for Research in Child Development, Serial No. 231, Vol. 58, No. 1. Chicago, The University of Chicago Press, v + 110 pp.

The objectives of this study were to develop a high-density chromosome bin map of homoeologous group 7 in hexaploid wheat, to identify gene distribution in these chromosomes, and to perform comparative studies of wheat with rice and barley. We mapped 2148 loci from 919 EST clones onto group 7 chromosomes of wheat. In the majority of cases the numbers of loci were significantly lower in the centromeric regions and tended to increase in the distal regions. The level of duplicated loci (...) in this group was 24% with most of these loci being localized toward the distal regions. One hundred nineteen EST probes that hybridized to three fragments and mapped to the three group 7 chromosomes were designated landmark probes and were used to construct a consensus homoeologous group 7 map. An additional 49 probes that mapped to 7AS, 7DS, and the ancestral translocated segment involving 7BS also were designated landmarks. Landmark probe orders and comparative maps of wheat, rice, and barley were produced on the basis of corresponding rice BAC/PAC and genetic markers that mapped on chromosomes 6 and 8 of rice. Identification of landmark ESTs and development of consensus maps may provide a framework of conserved coding regions predating the evolution of wheat genomes. (shrink)

A total of 1918 loci, detected by the hybridization of 938 expressed sequence tag unigenes from 26 Triticeae cDNA libraries, were mapped to wheat homoeologous group 4 chromosomes using a set of deletion, ditelosomic, and nulli-tetrasomic lines. The 1918 EST loci were not distributed uniformly among the three group 4 chromosomes; 41, 28, and 31% mapped to chromosomes 4A, 4B, and 4D, respectively. This pattern is in contrast to the cumulative results of EST mapping in all homoeologous groups, as reported (...) elsewhere, that found the highest proportion of loci mapped to the B genome. Sixty-five percent of these 1918 loci mapped to the long arms of homoeologous group 4 chromosomes, while 35% mapped to the short arms. The distal regions of chromosome arms showed higher numbers of loci than the proximal regions, with the exception of 4DL. This study confirmed the complex structure of chromosome 4A that contains two reciprocal translocations and two inversions, previously identified. An additional inversion in the centromeric region of 4A was revealed. A consensus map for homoeologous group 4 was developed from 119 ESTs unique to group 4. Forty-nine percent of these ESTs were found to be homoologous to sequences on rice chromosome 3, 12% had matches with sequences on other rice chromosomes, and 39% had no matches with rice sequences at all. Limited homology was found between wheat ESTs on homoeologous group 4 and the Arabidopsis genome. Forty-two percent of the homoeologous group 4 ESTs could be classified into functional categories on the basis of blastX searches against all protein databases. (shrink)

The focus of this study was to analyze the content, distribution, and comparative genome relationships of 996 chromosome bin-mapped expressed sequence tags accounting for 2266 restriction fragments on the homoeologous group 3 chromosomes of hexaploid wheat. Of these loci, 634, 884, and 748 were mapped on chromosomes 3A, 3B, and 3D, respectively. The individual chromosome bin maps revealed bins with a high density of mapped ESTs in the distal region and bins of low density in the proximal region of the (...) chromosome arms, with the exception of 3DS and 3DL. These distributions were more localized on the higher-resolution group 3 consensus map with intermediate regions of high-mapped-EST density on both chromosome arms. Gene ontology classification of mapped ESTs was not significantly different for homoeologous group 3 chromosomes compared to the other groups. A combined analysis of the individual bin maps using 537 of the mapped ESTs revealed rearrangements between the group 3 chromosomes. Approximately 232 of the consensus mapped ESTs matched sequences on rice chromosome 1 and revealed large- and small-scale differences in gene order. Of the group 3 mapped EST unigenes ∼21 and 32% matched the Arabidopsis coding regions and proteins, respectively, but no chromosome-level gene order conservation was detected. (shrink)

A total of 944 expressed sequence tags generated 2212 EST loci mapped to homoeologous group 1 chromosomes in hexaploid wheat. EST deletion maps and the consensus map of group 1 chromosomes were constructed to show EST distribution. EST loci were unevenly distributed among chromosomes 1A, 1B, and ID with 660, 826, and 726, respectively. The number of EST loci was greater on the long arms than on the short arms for all three chromosomes. The distribution of ESTs along chromosome arms (...) was nonrandom with EST clusters occurring in the distal regions of short arms and middle regions of long arms. Duplications of group 1 ESTs in other homoeologous groups occurred at a rate of 35.5%. Seventy-five percent of wheat chromosome 1 ESTs had significant matches with rice sequences, where large regions of conservation occurred between wheat consensus chromosome 1 and rice chromosome 5 and between the proximal portion of the long arm of wheat consensus chromosome 1 and rice chromosome 10. Only 9.5% of group 1 ESTs showed significant matches to Arabidopsis genome sequences. The results presented are useful for gene mapping and evolutionary and comparative genomics of grasses. (shrink)

This response offers an interpretation of James Gustafson's “Participation: A Religious Worldview,” which thinks with Gustafson on the theme of “participation,” while highlighting points where my own thoughts diverge from his. The essay begins by drawing the reader's attention to Gustafson's style, arguing that the simple elegance of his writing constitutes part of his larger claim about the need to remove ourselves from the center of our thought. Next, the essay analyzes Gustafson's use of “participation” by (...) putting it in context and connecting it with his broader methodology. Finally, I draw the reader's attention to important loci in the text in order to show how Gustafson's essay helps address various extant misinterpretations of his thought but also to point to ways in which my “thinking with” Gustafson leads me to think otherwise than he does. (shrink)

The roots of religious faith–and the provenance of ethical thought–may be sought in the human sciences, the physical sciences, literature, religious traditions, and deep human intuitions. Gustafson's religious stance and the author's, while different on their face, in common reflect a mingling–and tangling–of skepticism, understanding, and transcendence. Let all of us hope and believe what we can.

The complex hexaploid wheat genome offers many challenges for genomics research. Expressed sequence tags facilitate the analysis of gene-coding regions and provide a rich source of molecular markers for mapping and comparison with model organisms. The objectives of this study were to construct a high-density EST chromosome bin map of wheat homoeologous group 2 chromosomes to determine the distribution of ESTs, construct a consensus map of group 2 ESTs, investigate synteny, examine patterns of duplication, and assess the colinearity with rice (...) of ESTs assigned to the group 2 consensus bin map. A total of 2600 loci generated from 1110 ESTs were mapped to group 2 chromosomes by Southern hybridization onto wheat aneuploid chromosome and deletion stocks. A consensus map was constructed of 552 ESTs mapping to more than one group 2 chromosome. Regions of high gene density in distal bins and low gene density in proximal bins were found. Two interstitial gene-rich islands flanked by relatively gene-poor regions on both the short and long arms and having good synteny with rice were discovered. The map locations of two ESTs indicated the possible presence of a small pericentric inversion on chromosome 2B. Wheat chromosome group 2 was shown to share syntenous blocks with rice chromosomes 4 and 7. (shrink)

This report describes the rationale, approaches, organization, and resource development leading to a large-scale deletion bin map of the hexaploid wheat genome. Accompanying reports in this issue detail results from chromosome bin-mapping of expressed sequence tags representing genes onto the seven homoeologous chromosome groups and a global analysis of the entire mapped wheat EST data set. Among the resources developed were the first extensive public wheat EST collection. Described are protocols for sequencing, sequence processing, EST nomenclature, and the assembly of (...) ESTs into contigs. These contigs plus singletons were used for selection of distinct sequence motif unigenes. Selected ESTs were rearrayed, validated by 5′ and 3′ sequencing, and amplified for probing a series of wheat aneuploid and deletion stocks. Images and data for all Southern hybridizations were deposited in databases and were used by the coordinators for each of the seven homoeologous chromosome groups to validate the mapping results. Results from this project have established the foundation for future developments in wheat genomics. (shrink)

Hastings Center Report, Volume 52, Issue 2, Page 21-31, March‐April 2022.